IDENTIFICATION OF MPOX M1R AND B6R MONOCLONAL AND BISPECIFIC ANTIBODIES THAT EFFICIENTLY NEUTRALIZE AUTHENTIC MPOX VIRUS

Identification of mpox M1R and B6R monoclonal and bispecific antibodies that efficiently neutralize authentic mpox virus

In 2022, the monkeypox virus (mpox virus, MPXV) exhibited global dissemination across six continents, representing a notable challenge owing to the scarcity of targeted antiviral interventions.Passive immunotherapy, such as the use of Slippery Elm monoclonal antibodies (mAbs) and bispecific antibodies (bsAbs), has emerged as a promising option for

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SEMA4D/VEGF surface enhances endothelialization by diminished-glycolysis-mediated M2-like macrophage polarization

Cardiovascular disease remains the leading cause of death and morbidity worldwide.Inflammatory responses after percutaneous coronary intervention M TOP led to neoathrosclerosis and in-stent restenosis and thus increase the risk of adverse clinical outcomes.In this work, a metabolism reshaped surface is engineered, which combines the decreased glyco

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Moderate beta-cell ablation triggers synergic compensatory mechanisms even in the absence of overt metabolic disruption

Abstract Regeneration, the ability to replace injured tissues and organs, is a phenomenon commonly associated with lower vertebrates but is also observed in Cattle mammals, in specific tissues.In this study, we investigated the regenerative potential of pancreatic islets following moderate beta-cell loss in mice.Using a rapid model of moderate abla

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